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Contrave is a prescription weight-loss medicine used to help adults with a body mass index (BMI) of 30 or greater (obese), or adults with a BMI of 27 or greater (overweight) who have at least one weight-related medical problem.


Contrave works by altering the activity of certain neurotransmitters in the brain, particularly norepinephrine, dopamine, and opioid systems, which play a role in hunger signals and the perception of rewards, thereby reducing appetite and cravings.


On average, people taking Contrave can expect to lose 2-5% of their body weight over 8 weeks, but results can vary. Common side effects include nausea, constipation, headache, vomiting, dizziness, insomnia, and dry mouth.

Expected Weight Loss Over 8 Weeks
Side Effects
5-10% of body weight
Reduces hunger and food intake
Nausea, diarrhea, constipation, voimiting, potential risk of thyroid C-cell tumors
2-5% of body weight
Decreases appetite and cravings
Nausea, constipation, headache, voimiting, dizziness, insomina, dry mouth, diarrhea
5-10% of body weight
Appetite suppression
Dry mouth, insomina, dizziness, elevated heart rate and blood pressure
5-10% of body weight
Reduces appetite and can make food seem less appealing
Dizziness, altered taste, insomina, constipation, dry mouth, tingling of hands and feet
HCG injections
Varies (not universally accepted as effective)
May supress hunger
Fatigue, irritability, restlessness, depression, fluid buildup(edema), swelling of the breasts in boys and me (gynecomastia)
Varied (limited evidence on effectiveness)
May aid in fat breakdown and metabolism
Mild diarrhea, upset stomach, rash at the injection site, nausea


Contrave might offer more benefits than some other weight loss drugs because it not only reduces appetite but also specifically targets cravings, which can be a significant hindrance to weight loss for many individuals. By addressing the psychological aspects of eating, Contrave may provide a more holistic approach to weight management.

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